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Contributor: Carlo Banez

Recently Edited Monographs (49 Total)

Vorinostat

Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA) is a member of a larger class of compounds that inhibit histone deacetylases (HDAC). Histone deacetylase inhibitors (HDI) have a broad spectrum of epigenetic activities. SAHA is marketed under the name Vorinostat, brand name Zolinza, for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It has been used to treat Sézary's disease.

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1 edit since May 19, 2008. Last edited Jul 27, 2008 by Carlo Banez (49).

Formoterol

Formoterol (INN) or eformoterol (former BAN) is a long-acting β2-agonist used in the management of asthma and/or chronic obstructive pulmonary disease (COPD). It is marketed in four forms: a dry-powder inhaler (DPI), metered dose inhaler (MDI), an oral tablet, and as an inhalation solution, under various trade names including Foradil/Foradile (Novartis), Oxis (AstraZeneca), Atock (Astellas) and Perforomist (Dey).

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4 edits since May 19, 2008. Last edited Jul 26, 2008 by Carlo Banez (49).

Dabigatran

Dabigatran is an anticoagulant from the class of the direct thrombin inhibitors. It is being studied for various clinical indications, for some of which it may replace warfarin as the preferred anticoagulant. It is orally administered as the prodrug dabigatran etexilate (marketed as Pradaxa since April in European countries and Pradax in Canada). It was developed by pharmaceutical company Boehringer-Ingelheim.

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5 edits since May 19, 2008. Last edited Jul 20, 2008 by Carlo Banez (49).

Tolnaftate

Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm. It is sold under several brand names, most notably Tinactin (Schering-Plough Corporation) and Odor Eaters (Combe Incorporated). Other brands are Absorbine, Aftate, Desenex, Genaspor, NP 27, Scholl and Ting. It has been endorsed by John Madden.

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3 edits since May 19, 2008. Last edited Jul 17, 2008 by Carlo Banez (49).

Xaliproden

Xaliproden (codenamed SR57746) is a drug which has been proposed for use in the treatment of Alzheimer's disease.

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2 edits since May 19, 2008. Last edited Jul 15, 2008 by Carlo Banez (49).

Doripenem

Doripenem is an ultra-broad spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It was launched by Shionogi Co. of Japan under the brand name Finibax in 2005, and is being marketed outside Japan by Johnson & Johnson. It is particularly active against Pseudomonas aeruginosa.

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2 edits since May 19, 2008. Last edited Jul 13, 2008 by Carlo Banez (49).

Etravirine

Etravirine (formerly known as TMC-125, brand name Intelence) is a drug approved in the United States for the treatment of HIV. Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTIs). Unlike the currently available agents in the class, resistance to other NNRTIs does not seem to confer resistance to etravirine. Etravirine is marketed by Tibotec, a subsidiary of Johnson & Johnson. On January 2008, the Food and Drug Administration approved its use for patients with established resistance to other drugs, making it the 30th anti-HIV drug approved in the United States and the first to be approved in 2008. It was also approved for use in Canada on April 1, 2008.

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3 edits since May 19, 2008. Last edited Jul 09, 2008 by Carlo Banez (49).

Ceftobiprole

Ceftobiprole (brand name Zeftera) is a next generation cephalosporin antibiotic with activity against methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, Pseudomonas aeruginosa, and Enterococci. It was discovered by Basilea Pharmaceutica and was developed by Johnson & Johnson Pharmaceutical Research and Development. It has been shown to be statistically non-inferior to the combination of vancomycin and ceftazidime for the treatment of skin and soft tissue infections.

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4 edits since May 19, 2008. Last edited Jul 09, 2008 by Carlo Banez (49).

Sitafloxacin

Sitafloxacin (INN; also called DU-6859a) is a fluoroquinolone antibiotic that shows promise in the treatment of Buruli ulcer. The molecule was identified by Daiichi Sankyo Co., which brought ofloxacin and levofloxacin to the market. Sitafloxacin is currently marketed in Japan by Daiichi Sankyo under the tradename Gracevit.

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2 edits since May 19, 2008. Last edited Jul 06, 2008 by Carlo Banez (49).

Ketotifen

Ketotifen fumarate (ophthalmic solutions marketed under the brand name Zaditor (Novartis) and Alaway (Bausch and Lomb)) is an H1-antihistamine/mast cell stabilizer available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis, or the itchy red eyes caused by allergies. In its oral form, it is used to prevent asthma attacks. Side effects include drowsiness, weight gain, dry mouth, irritability, and increased nosebleeds.

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2 edits since May 19, 2008. Last edited Jul 03, 2008 by Carlo Banez (49).

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